Drug Interactions Put 1 in 5 Seniors at Risk: What You Need to Know

Dangerous drug interactions are a real risk for millions of older Americans, according to a new study published September 24 in JAMA. Researchers found that more than 1 in 5 adults ages 62 to 85 take medication combinations that could trigger a potentially major interaction. If you juggle several prescriptions and a few supplements, this essential research is worth five minutes of your time.

Why Drug Interactions Matter to You

Most of us add medications slowly over the years. A statin here, an antidepressant there, a daily fish oil because a friend recommended it. Each one may be fine alone. Together, they can change how your body absorbs or clears a drug.

The study, led by Dima Mazen Qato of the USC Mann School of Pharmacy, found that 35.7% of older adults now take five or more prescriptions at once, up from 31% in 2015–2016. That practice is called polypharmacy. Interactions can raise the risk of bleeding, falls, confusion and hospital stays.

Key Facts About Drug Interactions in Older Adults

Researchers used national data from nearly 5,000 adults living at home. They compared 2015–2016 with 2021–2023. Here is what changed:

• Prescription polypharmacy rose from 31% to 35.7%.
• Supplement polypharmacy (five or more supplements) rose from 12.6% to 16.7%.
• Risky combinations dipped slightly, from 25.7% to 22.3%, but still affect more than 1 in 5 people.

The drugs most often involved were antidepressants, statins and antiplatelet medicines (blood thinners such as clopidogrel that stop platelets from clumping). Qato said safety efforts should focus on these common combinations, especially those involving antidepressants.

What This Means for You

You do not need to stop any medicine on your own. Stopping suddenly can be dangerous. Instead, use this study as a reason to review everything you take with a professional who can see the full picture.

How Do I Know What I’m Really Taking?

Make one complete list. Include every prescription, over-the-counter pill, vitamin, herbal product and supplement, plus the dose and how often you take it. Keep a copy in your wallet and one on your phone. Update it every time a doctor makes a change. A complete list is the single best tool for spotting risky combinations.

Should I Ask for a “Brown Bag” Review?

Yes. Put every bottle in a bag and bring it to your doctor or pharmacist. This is called a brown bag review. Ask plainly: “Do any of these interact? Is there anything I no longer need?” Medicare Part D plans often offer a free Medication Therapy Management review for people on several drugs, so call your plan to ask.

Are Supplements Really Part of the Problem?

They can be. Supplement use is rising fast, and many people never mention them to doctors. Fish oil, ginkgo and some herbal products can add to the effect of blood thinners. St. John’s wort can clash with antidepressants. Always tell every provider about supplements, and try to fill all prescriptions at one pharmacy so its system can flag conflicts.

Looking Forward: Safer Medication Habits After 50

The good news is that risky combinations are slowly declining. Awareness works. Pick one step this week, whether that is writing your list or booking a pharmacist review. For more ways to stay ahead of health risks, read our guide on how adults over 50 can stay protected during measles outbreaks and our report on a new cancer breakthrough offering hope to older adults. You can read the study summary from USC Mann School of Pharmacy.

This article is for general information and is not medical advice. Talk with your doctor or pharmacist before changing any medication.